Also known as Trisomy 21. With 23 pairs of chromosomes, a person with Down Syndrome (i.e., a retard) has an extra 21st chromosome, causing several physical and mental defects. Usually easily recognized due to the retarded shape of their face and the clueless, happy expression on their face. These poor brain-dead sacks of sweaty garbage might be able to hold down a job as a greeter at Walmart, but this is about as high up the corporate ladder that these circus freaks typically go.
"Oh my god, did you see that dipshit window-licker trying to parallel park a shopping cart? What a down syndrome, fat fucking gay retard, fucking just dumbass stupid fucking loser. Let's kill him. I'll drown his ass, what a fucking puke piece of shit."
by Jack-the-stripper-ripper May 2, 2025
Get the Down Syndromemug. 
by Jœ mamæ August 1, 2022
Get the Down badmug. 
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by Gamerfrisk June 22, 2017
Get the FOOT DOWN!mug. by Onte May 23, 2024
Get the lay down tarmug. by 55arBallLicker May 19, 2021
Get the down carrymug.