This comes from the streets, man! Often referred to in rap songs. It indicates the need to have the gangsters "up" or on top of things, and keep the Ho's (bitches) down. Thought to have originated from pimps who would say it to indicate their whores were on their backs making the money for the pimps. Often said when greeting a fellow G, or upon entering a room or party. Meant to re-assure
G1: Greetings. G's up, ho's down.
G2: Fo' shizzle, ma' nizzle. Word.
by Gacis June 2, 2004
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2 fingers up makes a V 2 fingers down makes an A
the word form of the sign for Virginia
You already know I'm from that 2 up 2 down.
by Jasmyne June 5, 2006
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Type of Mdma aka Ecstasy popular on the east coast (especially Georgia and south Florida.

Its supposed larger dose of mdma causes it to be more expensive than "normal E"

Example prices of a city in south florida:
Regular E: $15 Each
Gs up: $20 Each
Yo man got some beans?
Fuck ya man I got some g's up hoes down lets roll on this shit
by Sn1p3r June 1, 2007
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true meaning:PIMPS stay up hoes stay down
PIMPS stay up(keeps money) by keeping his down to make that money. Only a true PIMP or hoe would know that though.
by sunshine December 1, 2003
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The mental collapse that can occur after the end of a relationship.
Claire was in the middle of a big break up break down so got wasted.
by Clairian April 23, 2011
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Getting pregnant or knocked up and then getting an abortion or losing the baby to a miscarriage or other misfortune.
Jenny- Did you hear? Amanda got knocked up and down over spring break
Ben- No way! You have to wait until the third month to get knocked down!
by grooved.out.152660 June 17, 2011
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