Someone who has smoked a viscous amount of methanphetamine creating a slurry of a brain/ someone with severe down syndrome
by Jamoneywoney June 3, 2021

by qazx528 June 26, 2010

What are you doing even talking about flame brain (someone that didn’t know what the fuck is going on) :((((
by Pheobe98 February 13, 2021

by I hate skibidi toilet November 15, 2023

by Non Partisan January 15, 2025

Big-brain, (Which can also be spelled without a hyphen,) means smart, intelligent, and is usually used when someone says something witty in an argument.
by ~Chrysanthemum~ December 2, 2020

The guilt that comes with leaving your city for a more affluent area after college, despite the best attempts of your professors and others to prevent it.
Paul: "I had this crazy dream last night. I was on trial for planning to move to Chicago, but the jury was made up of my professors. When the judge asked for the verdict, one of them stood up and said, "We have no verdict. We're just extremely dissappointed in him."
Bob: "Sounds like you have a serious case of brain drain guilt bro."
Bob: "Sounds like you have a serious case of brain drain guilt bro."
by Simon Dylan October 8, 2011
