When whatever is being referred to is doing something it is not supposed to be doing or taking a form it is not usually in. Mostley used in dark humor.
by Bjapayot3 March 9, 2019

Running from 2015 - 2017, "Whats up with" was a YouTube series by Peter Knetter. First episode "What's Up With: Sonic and the Black Knight" first aired on Nov 23 2015. The series was where Peter (Peter Knetter) talks to cardboard characters.
Peter (2015-17)
Silver (2015-17)
Shadow (2015)
Sonis (2015-2016)
Chuckles (2015-2016)
Mario (2016)
Nick (2017) *as of "Whats Up With: Sonic's Schoolhouse"*
Peter (2015-17)
Silver (2015-17)
Shadow (2015)
Sonis (2015-2016)
Chuckles (2015-2016)
Mario (2016)
Nick (2017) *as of "Whats Up With: Sonic's Schoolhouse"*
by aripods September 13, 2021

by Arminkshipper June 15, 2025

Random friend: "What's up?"
You: "I dunno"
Random friend: "You fool, you fell right into my trap, the sky is up there ya lil bish"
You: "I dunno"
Random friend: "You fool, you fell right into my trap, the sky is up there ya lil bish"
by getrekthoney October 24, 2019

Getting pegged with a carrot and then having your partner take a bite out of it explaining “Eh, what’s up Doc?”
Jessica brought a carrot into the bedroom last night. I knew instantly she wanted some What’s up Doc?
by Nomad13 June 5, 2024

Street Slang Meanin' What's Goin' On?, Whazzup?, Whazz Up?, Wassup?, Sup?, Sup Witchu?, Sup Witcha?, What's Poppin'?, Whazz Poppin'?, What's Happenin'?, What's Hanninan?, How Are You Doin'?, How Yew Doin'?, How Are You?, How Yew?, How Are You Feelin'?, How Yew Feelin'?, What's Trendin'?, What's New With You?, What's New With Yew?, What's New Witchu? & What's New Witcha?
"Yo Killa Cam!! What's Up? Zero. Erstreet At Ever Soo Much At Ever Str8 Thuggin', Ever Str8 Stuntin' & Ever Livin' Life Fully." - Erstreet Harlem aka Harlem, Flea, Kiery Weiry & Freshley.
by Hzr February 24, 2022

A common saying/ greeting in the madden gaming community. Popularized by a streamer named Sketch. It is customary to raise you index finger while using this saying/ greeting.
by PEEPEEHands04 May 6, 2024
