Up Syndrome

Up Syndrome is when someone with Down Syndrome is high off weed

“Bro is he ok”
“Nah he’s having a bit of Up Syndrome”

by Wild Warren December 13, 2020

Up Syndrome

When someone tends to hover above chimneys

Dolly has up syndrome, look at her hovering

by Dick Massive June 30, 2021

Up-syndrome

A person who is seriously ugly to the point no one wants to look at them without protective goggles.

That guy has up-syndrome, he’s such an uppy

by Lickle bump February 25, 2022

Up syndrome

When someone looks like they have down syndrome but they actually don't

Or do they

he looks up

he look he has up syndrome

by v842 November 18, 2022

up syndrome

when you have so much down syndorme it inverts itself

"jozlen sussy jol" up syndrome

by jolzen December 1, 2022

up syndrome

when your syndrome is down but your money is up

"my syndrome may be down but my money is up, And that's why they call it up syndrome,,

by the big fat rat November 13, 2023

Up syndrome

you say it to insult someone

you don't have down syndrome you have Up syndrome

by MangoMane January 25, 2025