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Commonly used as a word for "For Sure" or Yes I Agree fully.
Cracker1: Yoh! I'd tap that ass anyday.
Wannabe Cracker: Fo' Sho!
fo' sho by Shak April 18, 2003
fo'sho is a totally cool and epic way of saying 'for sure'.

commonly used by such celebrities such as christofer drew and alex gaskarth. fo'sho is sometimes referred to as a 'chris thaaang'.
loren and katie are dons fo'sho.
fo'sho by laaaaa:) January 16, 2011

Fo Sho Do 

A response to a question that is completely boss. The person who is asking it knows its an obvi answer and there's no doubt that its happenin'!
"Yo dog, you wanna go hit up some of dem cheap spaghetti ho's?"
"Fo Sho Do!"
"Ight!"

Hoe fo sho 

A female that is undeniably slutty, from the way she walks to the way she dresses. There are no doubts about her.
- "Hey Melvin, did you bang Jaunita last night?"

- "Damn straight nigga, she's a hoe fo sho."
Hoe fo sho by Melvin_Lover August 13, 2006
A shot to the head.

It is said in the tv show Gangland when Do was describing a way to do a hit.
"We had a, uh two guys, we called them Double Trouble. One person would hit you in the body, which would drop you, and the other person would put the what we call the fo' sho'."
Fo' Sho' by daboodeef179 September 23, 2011