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Depending on who you are referring it to, it has several meanings. For males it it used to call one a faggot, homo, flammer, or queer. For females it is to call one a slut, hoe, tramp, skank, and the list goes on.
ie. International House of Dicks.
Your mom is such a fucking I.H.O.D. I saw her on tampabaybukake.com!

I swear your brother is an I.H.O.D. 'cuz he keeps checking out my package!
I.H.O.D. by Dropinonmypipe August 21, 2008

I.H.O.P!!! 

boy 1"did you hear that tom got killed at the I.H.O.P!!yesterday?"
boy 2"the international house of pancakes?"
boy 1"no the International house of Pain!!! or I.H.O.P!!! for short"
I.H.O.P!!! by mad man mad man April 11, 2009

I.H.O.P. 

a hard hit in football. refering to the common slang of pancake for the same meaning.
the d-back came out of nowhere and "i.h.o.p.'d" me.
I.H.O.P. by daniel thomas June 19, 2006
S - sad
I - inside

H - happy

O - outside
Person 1: I'm always Smiling but I'm really hurting inside

Person 2: So your feeling very S.I.H.O

Person 1: Yeah! pretty much
S.I.H.O by XXXPUSSYLIPS September 29, 2018
in need of head
i told my girl friend i was diagnosed with i.n.o.h and she got scared and then later found out i was in need of head
i.n.o.h by whataqueer05 September 4, 2021

H.S.I.O.W. 

Holy Shit It's Only Wednesday
you'll drink more thinking it's Wednesday all the time
It's the middle of the week!!?...H.S.I.O.W. I need a drink!
H.S.I.O.W. by The Blood Virus February 21, 2009