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"Big Smoke" often refers to a large amount or extreme amount of smoke a person blows out, exhales, during the process of smoking.

Big smoke is a term used when two (2) or more people gather as a group, in a room, a car, or any place that allows smoke exhalation, (blowing big smoke), to be most visible.

When illegal drugs are used to get high, using the method of smoking the particular drugs such as meth or marijuana. Usually done from a oil burner aka meth pipe, rolling paper, bong, aluminum can, etc. Followed by observing of the amount of smoke in the room.
"We blew so much big smoke in his truck on our way to the casino, that when we opened the doors, the truck looked like it was on fire!"
Big Smoke by GiGi1111 June 15, 2018

oh man, check out "special agent big smoke" 

big smoke: CAP YOUR ASS
big smoke: AND YOUR ASS
big smoke: YOU WANT SOME, TOO?
big smoke: ICE COLD BABY
big smoke: I KNEW I WAS THE CHOSEN ONE
CJ: oh man, check out "special agent big smoke"
A guy from GTA
Big Smoke: I'll have a number nine, a number nine large, a number 6 extra dip, a number seven, two forty-fives, one with CHEESE, and a large soda
CJ: Fat boi
Big Smoke by Trisced1 August 24, 2019

The Big Smoke

Formerly known as The Pale, An iconic assortment of costume shops and pubs located on Ireland’s Eastern coast. Other sudonyms include; the capitol, town and less commonly, Dublin
I’m going up to the big smoke to buy a Jack Sparrow costume for Halloween
Big Smoke,Character in Grand Theft Auto:San Andreas hes overweight,mean when he has 2 be,but hes sstill understanding person
if i need food, i go ask my homie big smoke "yo gimmie some food u fat fool!"
A Large Obese Black Individual, Usually Accompanied By A Hunger For Hamburgers Or Excessive Amounts Of Edible Materials.

Including Ass.
DAMN, THAT NIGGA IS A BIG SMOKE, HE ATE THAT WHOLE ASS
Big Smoke by Niggaslayer69 July 18, 2019