Refers to the movie of the same name where one character tells another "if you ever kill someone, never tell anyone else about it.' If you do anything wrong keep it to yourself.
"Bob sent me a email about how he stole a laptop from work. Way to violate the Layer Cake Rule"

"I really wanted to tell the guys how I scored with that waitress on my business trip, but I thought of the Layer Cake Rule, and how it could get back to my wife."
by SnowPatrol July 30, 2010
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When a large group of bros are talking in a strictly-guy conversation, and a girl tries to jump in and contribute
Jessica caused a hole in the brozone layer when she tried to join into a conversation about last night's party that the jocks were having
by Jakers September 4, 2015
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when you cum on your significant other and the cum dries
"I hung out with Larry last night and he gave me a 2nd layer of skin."
by christiangrey March 27, 2015
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The stratum corneum (Latin for 'horny layer') is the outermost layer of the epidermis. The human stratum corneum comprises several levels of flattened corneocytes that are divided into two layers: the stratum disjunctum and stratum compactum. The stratum disjunctum is the uppermost and loosest layer of skin. The stratum compactum is the comparatively deeper, more compacted and more cohesive part of the stratum corneum. The corneocytes of the stratum disjunctum are larger, more rigid and more hydrophobic than that of the stratum compactum.

The stratum corneum is the dead tissue that performs protective and adaptive physiological functions including mechanical shear, impact resistance, water flux and hydration regulation, microbial proliferation and invasion regulation, initiation of inflammation through cytokine activation and dendritic cell activity, and selective permeability to exclude toxins, irritants, and allergens. This layer is composed of 15–20 layers of flattened cells with no nuclei and cell organelles. Their cytoplasm shows filamentous keratin. These corneocytes are embedded in a lipid matrix composed of ceramides, cholesterol, and fatty acids.
by epicthing July 30, 2021
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The holy supreme of all burritos
I just got 10 beefy 5 layer burritos from taco bell and obtained a god complex
by ToxicSenpaii February 8, 2021
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The massive skid mark left behind after eating, digesting, and farting out Taco Bell. These usually can NOT be washed away.
I am not gonna eat at Taco Bell for awhile, I destroyed my skivies with a 7-layer underwear wrecker. It will never come out.
by Mutchler January 21, 2006
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A mixture of vomit (guacamole), the greasy secretion that can be found in between a fat chick’s roll (cheese), diarrhea (beans), sperm (sour cream), pubic hair (lettuce), menstrual fluid (tomatoes), and pubic crabs (rice). All of this is served between a fat lady’s fat roll which serves as the tortilla.
I gave your mom a Seven Layer Burrito last night.
by Juan C. Lopez November 29, 2007
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