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the best friends 

1. A vulgar term which means the male penis and the female vagina; basically saying that the penis and vagina are best friends.

2. Your 'person' who will be there for you no matter what. Who shares their secrets, and laughs at your corny inside jokes and practically lives at your house. Who, if hurt by you, wil tell you to your face, and apologize if they hurt you. If they don't either you're wrong, or they're just not your best friend
guy: hey ya know, we're best friends in a way

girl: (thinks to herself: AH HELL NAH!)
in which way?

guy: because of our genitals! my penis is your vagina's best friend! they're the best friends, right?

girl: (thinks: OMIFRIGGINGOSH!)
*SLAP, SLAP* YOU ARE SUCH A PERV AND AN ASSHOLE!
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The Best best friends 

In a friend group of four there is always two friends who tell their problems to the other two so the other two always help them with their problems. The Best best friends also like to ship them and do everything for them to be together.
Cool girl:oh look at those love birds,we really are the best best friends
Alehandro:ikr

best friends on the side

The act of a subset of people from a group of mutual friends engaging in a side friendship.

Also shortened to "BFOTS"
"Oh so y'all hung out last night without ME? Talk about Best Friends on the Side!"

"Wait where was my invite when yall was BFOTSing?"

friends with the best benefits 

friends who do nothing but make out and have sex
X: Johnny got laid like 4 times yesterday.
Y: Yeah, I heard him and Jenny are friends with the best benefits

Best friends with the Corner Flag 

When you're playing Fifa Pro Clubs and your mate doesn't cross it in until he's at the corner of the pitch.
Cameron, stop being best friends with the corner flag!

The Best Friend Speech 

The speech given (usually to a guy) by a girl when he's started a relationship with her "best friend"
"Mate, i'm in deep shit... i spent last night with jane but i really am not intrested in a relationship"

"Yeah so what's wrong"

"Ellie gave me the best friend speech"

"she..."

"yeah..., the...'thing is...she's my best friend, if you fuck her around I will castrate you and stick your balls so far down your throat you'll be shitting cum for a month...' speech"

the guy best friend 

1) when something amazing happens, he's the one you want to tell first.
2) he's not afraid to tell you when you are with the wrong guy.
3) he's the first one you call when things are going wrong.
4) he's the first one there when you need a shoulder to cry on.
5) when you imagine your perfect guy, you see him in your mind
6) your friends wonder why you and him aren't together yet.
7) he wants to be your back up date for formal, in case something goes wrong with the 'jerk' you are taking.
8) he knows when things aren't right, no matter how many times you lie using the words 'i'm fine..'
9) he gives you amazing advice on guys, cause duh.. who knows them better?
10) he is amazing in every single way and treats you the way you ought to be treated..
hint:
keep the guy best friend in your life! He will always be there for you no matter how shitty you treat him. He loves you and lets face it, you guys are meant to be together! It may take weeks, months or years..but you will end up with him. :)