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It simply means.

WHAT THE F*CK ARE YOU ON?

Say it to someone who says something completely f*cked up...

Or someone on drugs, and you really want to know, what the hell they are smoking.
GUY#1: I think I just saw a purple elephant drinking my beer in the kitchen...

Guy#2: Dude, wtfruo?
WTFRUO by claudzxrawr January 20, 2010
Related Words
wtfruoa means "wat the fuck are you on about?" can allso mean who the fuck are you on about? usally used on msn, can be used both as a question or as a exlamation. also see related to wtf.
did you sleep with him?

who?

that guy you hooked up with last night, you know the one with brown hair in that grey top?

urmmm wtfruoa?
wtfruoa by 09xuereba April 27, 2008