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Big Brian 

A phrase used in place of “big brain” when choosing to express emotion over someone’s actions. On the Big Brian scale, the starting point is small Brian, ultimately representing someone who isn’t the brightest crayon in the box. The scale then goes up into a point at the top; medium Brian, representing someone who has intellectual value. It then goes back down; Big Brian, again representing someone without intellectual value. Brian is the small man living in your head, he controls everything you do, and documents all your thoughts. When he is small he can’t reach the drawers, when he is big he is stumbling over things.
Man- “Hey look at that bro, he just tripped and fell!”
Man 2- “Hahahaha, big brain”
Man 3- *slowly turns towards man 2, and chokes him* “Excuse me Brendon...I think you mean big Brian.”
Big Brian by Banke February 22, 2020
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Big brian 

Intentional misspelling when you’re too dank for the usual “big brain” meme.
Bisexuality is just Scrödingers Gay.”

Ah yes, big brian time.”
Big brian by obamaworshipper18 December 14, 2019

Big Brian 

Person 1: I have a big brian
Person 2: it's brain idiot >:(
Big Brian by BigBrain200iq October 27, 2019

big brian 

When you want to tell your friends how smart you are, and it backfires when you misspell the easiest shit ever. You are now big brian.
Sid: Yo Grxffiti I am so big brian
Sid: brain*
Grxffiti: smh my head sid
big brian by Grxffiti August 1, 2021

Big brian 

A person who thinks he is smart but in reality he is a stupid idiot
Burger king is good

Bro is “big brian
Big brian by Chuck687 June 20, 2023

Big Brian Ilel 

A guy who plays valorant with yolor3stis and Tetoris and has taken the istanbul servers by storm with his big brain plays on the agent Omen.
Omg clip that, that was suck a Big Brian Ilel move
Big Brian Ilel by Ilel kalliakmeme October 26, 2020

Big Man Brian

Big Man Brian is the nickname give to the obese principal of Innisdale Secondary School, in Barrie, ON. Big Man Brian is often seen spying on students, getting mad for no reason, or just looking like a dumbfuck.
A: Hey look up in the window
B: What?
A: Big Man Brian is staring at us with his fatass face
Big Man Brian by HeyThere2310 October 26, 2022