cryo-vac Share definition Flag When something is so tight that it looks like it has been both cryogenically sealed and had the air vacuumed out of it. "WTF is Jimmy wearing? It looks like he's cryo-vac'd his pants on!!" cryo-vac by The Sync December 18, 2008 0 0 Get merch Get the cryo-vac mug. Buy Now — $32.95 See more merch