Pennsylvania Avenue 

1)The only street more crooked than Lombard Street.
2)The street on which the White House is stationed.

Pennsylvania Avenue is horrible

Pennsylvania Avenue by Slatte December 10, 2006

Pennsylvania Avenue 

Pennsylvania Avenue is a street in Baltimore City (the heroin capital of the world) that is populated by the highest population of heroin dealers and users in the city.

Damon: I'm outta dope man, I'm heading down to Pennsylvania Avenue.
Damon's Friend: Watch out down there, don't get your ass capped.

Pennsylvania Avenue by B-more Bro July 20, 2008

Pennsylvania Avenue 

The region of the colon between the rectum and the anus. See: pennsylvania chocolate pie, Pennsylvania Pinecone, and pennsylvania press.

"I've got a giant dump comin' right down Pennsylvania Avenue."

"What a coincidence! I'll have a giant load going the other way tonight!"

Pennsylvania Avenue by Ep Onymous August 20, 2007