Jesus Louisus Share definition Flag An expansion of jeez Louis. Used in bewilderment or frustration, but normally in a humorous tone. "Jesus Louisus, how many words are in this urban dictionary!?""Will you hurry up? Jesus Louises!" Jesus Louisus by Frostkat December 30, 2020 0 0 Get merch Get the Jesus Louisus mug. Buy Now — $32.95 See more merch