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A drug dealer or runner who is from Mexico. He speaks little to no english and probably has multiple low-end vehicles. The only english he understand is numbers and major cross streets of your city. Primarily he usually sells crystal meth or heroin. His prices for drugs are always the best around town.
That damn Paisa got the location wrong. I told him 69th Avenue and he's on 69th street.
Dude my Paisa has some fire lets call him so we can score some.
I lost my Paisa's number!!!!!!!!
Paisa by PhxSid September 1, 2017
Related Words
Prison organization majorly composed by Mexicans and latinos. Often seen using the number "16" in tattoos & logos. The number sixteen represents the letter ("P" for Paisa) in the alphabet. Paisa is also spanish Word for "Hometown or Homeboy".
"When I hit the pen I'm going to run with the paisas".
Paisa by Mexiclekdt December 21, 2018
A person from Colombia that is from the Antioquia region, most referred to Medellín, also where the hottest girls are and the best accent 😩
where you from?”
“i’m paisa, don’t u hear my accent
“knew it”
paisa by Hoodking November 2, 2021
A Mexican whose Mexican-ness comically interferes with a white-washed society
“Bro, I can’t hear the Patriots game over the neighbor’s mariachi music! Fucking paisa.”
Paisa by ashtonembry December 24, 2022

paisa fever 

when a person is attracted to mexicans, mexican-american, or the likeness of mexicans both physically and sexually
Oh my god, i think that mexicano is like so totally hot!
you have Paisa Fever
paisa fever by Bonito October 29, 2007

Paisa Cauca 

A White Colombian born or raised in Antioquia (Medellin) Colombia who is of European descent, French, Spanish, Basque, British, German and who's ancestors came to Colombia during colonial era of the 16th to 19th century. Normally raised in Poblado or one of the more affluent "white" suburbs of Medellin.
That Paisa Cauca is better dressed than any gringo.
Paisa Cauca by Ernesto Gaitan June 30, 2008