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Not to be confused with muffin. It is a very funny joke that makes everyone "laugh"...and by laugh I mean role their eyes and chuckle.
Jess: What's up
John: Nuffin
Jess: oh...
John: NOT TO BE CONFUSED WITH MUFFIN
Nuffin by FromKatlyn+John September 8, 2018
Whatcha doin?
Nuffin.
Sounds yummy.
nuffin by someguy1234567890 December 6, 2006
A muffin that does not contain (throughout its inner cake) any of the ingredients displayed on the top of the muffin. Term can be applied to people in an organisation who appear to do work but who achieve little.
You buy what looks like a delicious fruit stuffed muffin but find that inside it is all cake and no fruit. It looks good but delivers nothing. It’s not a muffin, it’s a nuffin.
Nuffin by The Process Ninja December 16, 2008
Whatcha doin?
Nuffin.
Sounds yummy.
nuffin by someguy1234567890 December 6, 2006
Nuffin is For someone that doesn't want to say nothing.
hey Steve, you ain't nuffin, you ain't nuffin!”
Nuffin by Mnj85 March 13, 2021

nuffin puffin 

Just to say 'nothing'. You know?
Person: "Okay, what're you up to now?"
Other Person: "Nuffin puffin beeyotch."
nuffin puffin by Werefrodo March 7, 2005