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what's up 

A question that means "hi" or "What are you doing"
It can get annoying, but people don't seem to understand that.
The best way to answer is "I think it's the opposite of down" if you are annoyed by this question
"What's up?"

what's up 

see also: whazzup, whassup, whasabi!!, etc.
1. Hi
2. Wtf is wrong with you??

It's probably originated from the late 20th century, when people were astounded with the sky. The only thing that they would reply was "nothing"

Probably the first term to the decline of western civilization
1. Person 1: What's up?
Person 2: "Nothing" (most common response, maybe 99% of people say that)

2. Person 1: What's up?
Person: "The sky" (smart alleck answer: also: "the ceiling" or, "da roof")

what's up 

Possibly derived from "what's the update." Extremely overused, almost exclusively by America's youth.
Sometimes I wonder why people always ask each other the same question over and over again, when answer is always "nothing." Are we really that dull?
Mike: What's up?
Matthew: Nothing. If you ask me again I'll roast you.

What's Up 

An extremely annoying phrase used by people who have never heard of "hello." Usually people ask this when they are bored, expecting the person they're asking to entertain them.
Guy: what's up?
other guy: *sigh* stop trying to make me entertain you.
What's Up by The Ironic Geek September 27, 2015

What's up 

Used to ask an indiviudal how things are going. Can be responded to in urban settings by using the word Chillin or in Jamaica by saying Cool
A- Yo man what's up?

B- Chilllin
What's up by ICO777 August 12, 2009

what's up 

what's up
what's up by XOXO, IG August 18, 2019