IQTB Share definition Flag Acronym for I Quit This Bitch. Most often used for an all around expression of frustration and quitting of a certain situation and or person. 1. Dude: Man, this chick is whack. IQTB2. Chick: The stupid candy machine doesn't work. IQTB IQTB by YouPoo July 27, 2009 0 0 Get merch Get the IQTB mug. Buy Now — $32.95 See more merch