A response used to show disbelief or anger at a statement made by your tightest of nigs.
Tightest Nig: "Yo for real when your fuckin a bitch let her slip her finger in yo ass son!"
You: "NIGGA PLZ!"
If you arrive at a social event and the vast majority of females there are ugly then the said event has a bad case of UglyBitches.
Man, I walked in there looked around and knew that his party had a bad case of uglybitches.