1 definition by Sky BobWalker the Nob-Hobbler
<Noun> A synonym for Crack Cocaine. Doing Oprah has become as world renown as playing with your friend Mary Jane is for marijuana. Originally thought to be an new phrase of the Ebonics style dialect of pop culture for obtaining or doing the impossible, law enforcement quickly realized their mistake after arresting a pregnant 15year old at the corner of Boss Gaston and Richmond Gaines in Huston TX, after she attempted to score some 'Oprah' from an undercover cop.
by Sky BobWalker the Nob-Hobbler April 2, 2011