Despite being an unfortunate condition that eventually leads to a weaker immune system, it has gained popularity as a reaction to something irrational or stupid said or done by someone, or simply to a pun or really bad joke.
Matt: Did you hear about the pornstar that got stuck between an ice cream truck and a truck full of pies? She nearly died!
Louis: Well, I guess she got... "creampied
Leo: Gosh, you just gave me aids!