1 definition by Icesakamami
Like saying "yo mama" but instead you say "ya sista" can be used for anything. More as an insult. Does not matter whether or not the person has a sister.
Guy 1:"Yo you looked like crap the other night at the party."
Guy 2:Ya sista looked like crap that sloppy hoe!"
Guy 2:Ya sista looked like crap that sloppy hoe!"
by Icesakamami November 9, 2007