Like saying "yo mama" but instead you say "ya sista" can be used for anything. More as an insult. Does not matter whether or not the person has a sister.
Guy 1:"Yo you looked like crap the other night at the party."
Guy 2:Ya sista looked like crap that sloppy hoe!"
Guy 2:Ya sista looked like crap that sloppy hoe!"
by Icesakamami December 03, 2007
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