The medical definition of a person with a brain so small that if you shine a light in their mouth, their whole head will light up like a Halloween pumpkin.
"He chopped his own finger off with a steak knife"
"What's the diagnosis, doctor?"
"Clearly pumpkin positive"
Being well and truly past the stage of being edible, even when you're totally intoxicated.
"How was your burger?"
"Totally Liza Minelli - I can feel it coming back up right now"