Quite literally the summation of the words “big” and “oof”. In other words, a quicker way of saying “big oof.” All drug-related references to the word are irrelevant in this context.
“Big” + “oof” = “boof”
Person 1 - “I accidentally uploaded my porn folder to the homework Dropbox. FML.”
Person 2 - “Damn, that’s a boof.”
