Variation on "your lips to Gods ears" - may the (perhaps improbable) wish you just typed be received by the Divine, and then brought to fruition. Another way to say, "Boy, I sure hope so!"
to unintentionally get knocked up or knock up someone else, leaving you with two courses of action: Call a professional, or use a coat hanger.
Guy 1: "So what's up with you and your fuck buddy?"
Guy 2: "Oh man, we have a problem."
Guy 1: "Dude, did you lock your keys in your car?"
Guy 2: "Yeah, out in the high school parking lot."
Guy 1: "Well at least you know your options."