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Contraction of the greeting "What's up?" which is a contraction of "What is up?" If you're really pressed for time, greet someone with a "sup"?. In any case, the greeter is rhetorically asking you what is going on in your life. Roughly synonymous with hello but less hip.
Hipster1: Wussup?
Hipster2: Nuttin'.
Hipster1: Word.
Hipster2: Word is bond.
wussup by Edward January 6, 2004
Related Words
The squished together slang word "wassup," also known as (wussup, wassssssssssssssup, wosssssssssssssup) and others originally stemming from the words " what is up " either meaning (how are you), (what are you doing) or even both at the same time.

Time went by, and the expression "what is up" became too long to say, type and text for the average lazy person. Therefore wassssssssup was invented.

Following this point, budweiser took this idea and made it their international slogan used on adverts, said by various strange frog people.

WASSSSSSSSSUP was then the word of the world and everyone, wherever they were, whether in an igloo in iceland, or in a whole in tikrit, (iraq), or in a cave in afghanistan, or even in some shitty trailer park in America, or Buckingham palace everyone could say "wassssssssup" without necesarilly understanding it.
daniel: " wassssssssssssssssssssup?"
alex: " not much, you?"
wussup by jimmeny cricket January 6, 2004

wutsplosion 

The process in which the brain enters a questioning pause where the person becomes oblivious to his/her surroundings when confronted with something totally new, ridiculous, or awesome.

Highly related to the words what (not the country), wut, and wtf.
The word simply refers to an Explosion of Wut.
In reaction to the Rare Exports movie trailer: "I think I just had a wutsplosion."

Girlfriend: "I think I'm pregnant."
Boyfriend: ........*wutsplosion*
wutsplosion by Teoyo September 16, 2010
when you are too lazy to type out "what is up?" Too lazy to even type "What's up?" No, this is an insult to English, and, yet, I myself use "Watsup?"
Dude: Hey!

Other Dude: Hey bro, watsup?

dass wussup 

"That's what's up", usually referring to something excting, and something that is of your interest.
"We're gunna party, and get laid!"

"Dass Wussup!"
dass wussup by Nicholexcore October 27, 2008
It's long for 'sup.

Also part of the Buddweiser commercial fad.
- Wassup dawg?!
- Yo dawg, 'sup?
wussup by zorpidus January 7, 2004