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To be so totally clueless as to not know where you are or where you are going when high on drugs... This can be brief or for some time.

Etymology: Where The Fuq aM I
I waz drivin back 2 ma crib along the usual path afta takin sum of dem mystery pillz, when all of a sudden i experienced a WTFMI moment... I did not kno wat road i waz on or where i waz goin .
WTFMI by CodegoErgoSum May 15, 2016
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Way Too Fucking Much Information

When TMI is not enough
"She started telling me about that rash she had, and I said WHOA WTFMI!"
WTFMI by Stirex February 5, 2010
Related Words
What the fuck is wrong with you?
Person 1: I pooped in the sink again
Person 2: WTFIWWY!?!
WTFIWWY by djasbestos August 3, 2007

WTFIGO - WTHIGO 

What the fuck is going on?
What the hell is going on?
WTFIGO - WTHIGO by qsc-forum.cjb.net September 2, 2003
An acronynm for "what the fuck is this shit". However, it is not used that often. Usually used when instant messaging. Also look at wtfiw
<Coolio> wtfits
<Kewlio> wtfiw
wtfits by Alec the Great December 19, 2004

wtfiuknwdysdstfuk 

what the fuck is up kyle no what did you say dude step the fuck up kyle
Kyle: dude thats a bad word!!
Steve: wtfiuknwdysdstfuk
Kyle: ... what the actual fuck dude
Steve: what the fuck is up kyle no what did you say dude step the fuck up kyle
Kyle: what did i ever do to you
"I think I'm gonna go skiing"
"Wtfit?"
"It's a sport which many people practise and you do it in snow!"
wtfit by Rio Comesaña December 27, 2007