A condition affecting the body's circadian clock, similar to jet lag, but instead stemming from altering one's sleep hours over a weekend of hard partying and drinking rather than from a long flight.
Franks: "Shit, I missed fluid dynamics again. Monday morning classes are so rough. It feels like it is 7 PM. What time is it?"
Jason: "It's only 8 in the morning."
Brad: "Fuck dude, that's a serious case of weekend lag. Drink some fluids and stop hitting the riverboat casino so hard in P-town."
by Fitterer September 25, 2006
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