A twiffle is widely considered as someone that is your best friend on the popular social networking site, Twitter.
"Hey, did you know that @davetran is my twiffle?"
by @swayLAY December 28, 2009
Can you define these popular missing words?
to tickle someone's butthole
Haha! I just twiffled him.
by RZA, Asain dude, and Capn A October 07, 2010