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1.
A twiffle is widely considered as someone that is your best friend on the popular social networking site, Twitter.
"Hey, did you know that @davetran is my twiffle?"
by @swayLAY December 28, 2009
 
2.
to tickle someone's butthole
Haha! I just twiffled him.
by RZA, Asain dude, and Capn A October 07, 2010
 
3.
A small and visually attractive vulva. One that hasn't been worn out or is stinky.
"I went out with the gymnast on Friday, oh man she has the cutest twiffle."
by Action_bastard April 19, 2009