when you've been up for forever on meth and are starting to trip hardcore - ie, when your face is beginning to become one giant open bleeding sore from picking at it.
"damn, i am so twacked out, i plucked until i dont have any eyebrows left."
"your pupils are so big you dont have any color in them - you're hella twacked out."
"for the last time, that is a MINIVAN, not the FBI - quit getting so damned twacked out!"
Originated in Stillwater, Oklahoma in 2000. When you've done too much tweak to the point where you are useless to the world. When you are so spun that you are get caught in the same repetitive motion until you run out of crank.
Damn, Tamara's been working on that crossword book for 3 days straight, someone take her dope away, she's twacked the f&#^ out.
When you're really high on meth or when you've been awake so long smoking dope that you're totally outta there! My friend was so twacked out on dope he thought that I was a cop.
I can't understandwhat the fuck you're saying cuz you're talking 100mph you're so twacked out.
I was so twacked out I thought there were undercover narcotics agents in the van parked across the street.