Someone who is a slut,whore, tramp, or turns trics. Referring mostly to females. She openly appears as a slut and is very forward in the way she approaches a male. She mostly performs sexual deeds for males and brags about it.

(origin: Philly particularly in the North East area)
That girl you're dating is such a tweeker. She slept with Jerome John and Darryl in one night.
by UD Girl 116 August 12, 2009
a tweeker is a whore. someone who loves to fuck and will let anybody hit.
yo i'm tryinna go get some tweekers and get chewed real quick
by r.i.p.mj July 07, 2009
Abbreviation for "two weeker", used to describe a person who does something or goes somewhere for two weeks. Sometimes spelled "tw'eeker" or "tw'weeker"
How long are you goin' to sleepaway camp?
I'm gonna be a tweeker
by Wolfdog August 30, 2007
a tweeker is someone acting like a retard. constantly flipping out over stupid shit. just plain fucking annoying.
The lady that works at the register was being a tweeker because the credit card was too close to the register.
by used4life August 08, 2005
a krunck non-sleepin,but hell yea be eatin who likes to twist tha pizzy fa shizzy my nizzy. Tha fool cleans betta than Mr. Clean. Ya got a new best friend cause they speak nothin but tha truth in tha end. Maybe bad and u may get sad, but while ur tweekin u aint nothing but glad. And you see them still seekin....and thats the definition of tweekin.
That Tweeker Rox!!
by Queen Tweeker January 25, 2004
1. Eric Howsen
2.Tommy Trotti also known as 007 known as new minglewood blues for stealing womens from their men.

Any way these two tweekers bug out and freak out all the time and always think people are ploting agingt them.
Eric Howsen and Tommy Trotti are both tweekers.

Those two tweekers should just simmer down.

Will someone give those two tweekers both a pill.
by trizz April 02, 2004
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