Show biz slang for hyper positive attitude. From the legendary rallying cry of the lead chorine for Broadway shows, just before they go on stage -- "Tits up, girls!" Usually an adjective -- a tits up attitude, taking the tits up approach, they want someone who's totally tits up for the job.
Everything is going to shit but my boss is so tits up I may have to kill him.

They want to see a lot of tits up attitude this quarter, when the new product rolls out.
by old lang guy October 17, 2006

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Origin: when any mammal has died and is on its back, it is "tits up". Things have gone titsup, meaning, the animal/situation has fallen down/gone wrong.
"Star Wars I, II would have been great, but Lucas became involved and the story-line went titsup!"
by colby March 24, 2005

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Expression to describe when a person or activity has run its course and met its end. Dead. Finished. Done. The expression is thought to have originated from military pilots when reporting from the air the visual status of other planes that had gone down and met their end, and in doing so on the way down or at their final resting place (or both), were often times "upside down" with their wheels pointing up rather than down as they operationally should have been. When seen from high above upside down with belly and wheels pointing up, they were described as they appeared....."tits up".
Hey...are the Cowboys going to the Superbowl or not?

What? No man....they lost last Sunday. It's over. They're tits up dude.
by DallasBB May 09, 2011

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Haywire
After an hour of flying the auto-pilot
went "titsup" and we crashed.
by Ron May 08, 2003

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It's like "catsup" only tastier.
Please pass the titsup.
by Hugo Frankenberry June 24, 2011

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Deader than fried chicken.
No, Molly, I'm sorry, I can't come over tonight. I have to stay at home with Mom. They found Dad tits up in the bathroom at the "Ponderosa" this afternoon.
by Gino Licata June 13, 2007

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Best used as a negative adjective when describing what you hope will result in a relationship, situation, or vacation.
I hope it goes tits up in Corfu.
by mggiedixon August 21, 2009

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Verb.
To head over to somewhere.
I'll tits up later and come and join you.
by LondonBird December 02, 2011

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