Dates back to the fatass era. Shortened rendition of What is up?(What's up?)
Sup, holmes
Sup with that hoe?
by Shadditude November 28, 2004
British upper-class term for an evening meal; a shortening of the word supper.
Hugo: "I tell you what Johnny, I'm rather famished!"
Johnny: "Well Hugo, why don't we do sups soon?"
Hugo: "Spiffing idea, old chap."
by Hanari M April 24, 2007
If one sips his own drink, one sups someone elses drank.
That looks good. Either give me a dollar er give me a sup of yors.
by Timothy Wooton September 21, 2006
Sup! is a greeting/verb. It defines meeting a female talking to or boning her.
Hi grandma! I sup!ped the shit out of this chick yesterday...she was good! Sup!
by IT DOESN'T MATTER WHO I AM July 26, 2009
half of the word whats up. Mostly used to reply to someone you hate.
erick: "Hey" (acting like a inocent little bitch)

keven: "sup" (in his mind he is thinking) im gonna kick his ass one day and make him gag on my cum.
1) The brief way of saying: "Hi, I'm really pathetic, what are you doing?"

2) Probably the worst response to any humane or initial greeting.

3) Okay if used when your under the influence, jocularly, and/or feel the need to be obnoxious for one hot sec.
1) Man sitting at bar with Corona: "'sup"
Woman trying to get a drink: "Oh! *Smacks forehead* I'm so sorry, but I don't understand all of the one word you just asked me or if it even if was a question at all"

2) Kind girl texting boy: Hey :) What's up??
Boy one hour later: "'sup."

3) Drunk tourist in cab: "Man, you do understand how epic tonight's gonna be, right?"
Hammered tourist friend: I know, dude! ETA 15 minutes... SUUUUUUUUUUUUUP ATOWNNN. We're about to Get It IN!
by laughingturtle February 26, 2011
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