when an angry militant black woman goes crazy
Rufus: I tried to set LaKeisha straight but da bitch went sista souljah on my ass.
Antionio: Damn, time to put a boot in da bitchs' mouth.
by Unkkle Crakker September 29, 2006
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Sista Souljah is a rap artist and was a vocal member of Jesse Jackson's Rainbow Coalition. During the 92 riots over the Rodney King beating, Sista Souljah made several racist statements encouraging senseless black on white violence. Her sound bites not only damaged her own reputation, but ultimately damaged Jesse Jackson's credibility. Presidential candidate Bill Clinton wasted no time jumping on this, and compared Souljah (and Jesse Jackson by association) to David Duke, a former Louisiana governor who was a leader in the Ku Klux Klan.

A Sista Souljah moment is when a black person damages their reputation by making a racist statement publicly.
Kanye West had a Sista Souljah moment when he interrupted Taylor Swift's MTV Music Award acceptance speech, yanked the microphone from her hand, and declared Beyonce should have won the award instead.
by ButtSmoothie September 14, 2009
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A large black woman with an attitude and a deep singing voice. EX: Aretha Franklin, Whoopi Goldberg
Latrell: "I hear you been poppin' LaKeisha lately. Got yo' self a soul sista I see."
Donell: "Hell naw nigga, that ho can't sing. She ain't nothin' but a BIG BITCH."
by Nick D February 9, 2004
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Ones Sister's breasts if they are the size of a "b cup"
by herrkraft February 2, 2007
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apparently meaning a very sassy girl.

verb: sista sledgin' (meaning smarting off, dissing, etc.)
Don't pop that attitude with me sista sledge!

Yes Tamara was totally sista sledgin' me today.
by Montyy_18 May 20, 2011
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Two, or more, unusually close girlfriends. They are highly suspected of "Twizza"-ing in there spare time...
A Twizza can find love in another females eyes and not think nothing of it.

Those Twizza Sista's sure are close
by CLO-Dawg August 19, 2010
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Two girls that have sexual intercourse with the same gentleman.
Amber: Hey Brittney, you screwed Matt?!? Yay! We are Mista Sista's!!

Brittney: Ya!! I heard you did too! He was awesome!!!
by DURB February 20, 2015
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