Top Definition
PKA, an acronym for Previously Known As, or Professionally Known As.
"The artist was previously known as William York"
"pka William York"
#p.k.a. #aka #a.k.a. #previously known as #professionally known as
by z33k December 18, 2007
Protein Kinase A

G protein-coupled receptor kinases (GRKs) represent a class of proteins that classically phosphorylate agonist-activated G protein-coupled receptors, leading to uncoupling of the receptor from further G protein activation. Recently, we have reported that the heterotrimeric G protein á-subunit, Gáq/11, can mediate insulin-stimulated glucose transport. GRK2 contains a regulator of G protein signaling (RGS) domain with specificity for Gáq/11. Therefore, we postulated that GRK2 could be an inhibitor of the insulin signaling cascade leading to glucose transport in 3T3-L1 adipocytes. In this study, we demonstrate that microinjection of anti-GRK2 antibody or siRNA against GRK2 increased insulin-stimulated insulin-responsive glucose transporter 4 (GLUT4) translocation, while adenovirus-mediated overexpression of wild-type or kinase-deficient GRK2 inhibited insulin-stimulated GLUT4 translocation as well as 2-deoxyglucose uptake. Importantly, a mutant GRK2 lacking the RGS domain was without effect. Taken together, these results indicate that through its RGS domain endogenous GRK2 functions as a negative regulator of insulin-stimulated glucose transport by interfering with Gáq/11 signaling to GLUT4 translocation. Furthermore, inhibitors of GRK2 can lead to enhanced insulin sensitivity.
The PKA for a common brown rat, in fasta format is:
#protein #ncbi #protein kinase a #science #rat
by Mr. Doctor Proffesor Patrick September 17, 2007
It stands for Pi Kappa Alpha. They are called PIKE's for short.

Their national slogan is "Men who love men to love them."

They tend to gravitate towards being firemen and love to shower together.
PKA? Pi Kappa Alpha?
(Group Shower)
#pike #pi kappa alpha #pka #pke #frat
by Jeffgdi January 13, 2008
a cult, based in maple ridge.
"PKA is the coolest cult ever"
by PKA March 13, 2005
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