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1.
something that is awesome, or the shit
"dude that shit is nizzer man!"
by Matt klamka August 11, 2005
 
2.
a funkay fresh negro.

What it do ma nizzer.
by Raychlle April 09, 2007
 
3.
Nizzer can mean whatever you want it to be. and it has nothing to do with the N word
why do u have to be such a nizzer? gosh im trying to have fun with you but u have to go nizzer on all this nizzer
by Rhyann July 08, 2005