An .NFO main use is to contain information about a certian computer system. Users can save their computer specification as a .NFO and share with others - usually for technical support reasons.

It is also used with pirate software packages by groups such as 'Paradox' who consider an .nfo as a way of being elite. If opened in notepad, the file is a simple text file, usually containing an ASCII logo, the software piraters name and the serial number to the package.
Paradox: Yes! We use .NFO's ! Everyone knows we mean business!
by SnipaMasta January 8, 2006
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Text files that contain information have the extension of ".nfo", so that it's easier to distinguish what is contained within.
by Infographics February 4, 2009
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The .nfo file included with a pirated software package. Those in the know will open this with MS Notepad, as it is actually a plain text file. The nfo usually contains a pirate "crew"'s ascii art logo at the top, which bears a resemblance to raw code to the uninitiated, and gets mangled into gibberish if opened in anything other than Notepad.

Usually associated with: ISO, crew, rar, crack, keygen, rip, reg, courier, 0-day.
Q: "I opened the rar from the 0-day. Many thanks to the courier & crew for this one; glad it's not a big ISO. But where's the serial number? Or do I have to use a keygen to reg this rip?"

A: "Just open up the nfo, newbie. The cereal is in there."
by Nupe January 7, 2004
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Nuke From Orbit
Reference to the movie Aliens. In computer jargon means to reformat and reinstall a system, erasing any data, and hopefully, any problem with said system.
Dude, this system is totally hosed. We should just NFO it and start over.
by Titaniumlegs February 5, 2008
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Nympho, nymphomaniac. A girl who wants to have sex a lot
You need to ask out Angela. She is a total nfo.
by KCQ August 12, 2007
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Near Fatal Orgasm

A highly volatile and incredibly pleasurable orgasm that takes the lucky bastard to the brink of death.
Jenny: Holy shit, Brandon Flowers just gave me a NFO!
Barry: You too huh?
by Busty Barry July 28, 2010
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A Nonsexual Facial Orgasm, this can be reached by relaxing your head and then rolling your eyes back while biting and touching your lip. The results are fantastic.
Dude, I did some serious Nfo-ing last night!

or
Brb, gonna have some nfo's quickly.
by R_Zombie12345 January 11, 2021
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