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The term is Spanish and literally means "Hand to Hand" as in unarmed combat. However in its modern incarnation the term is used in any scenario where two (usually male) individuals are going to have some sort of competition. Eg Darts, Snooker, an actual fight, even videogames. It is rarely a serious threat.
"Come Hotshot think you can take me at Multiplayer goldeneye? Huh? Ok just you and me Mano a Mano"
by Jack Karch May 29, 2006
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This expression could come either from italian or spanish, it literally means "hand to hand" and it is used to indicate an argue, a verbal fight between two people.
"I had a mano a mano with John yesterday, i hate when he talks to me like that."
"You and John should stop with those head to head discussions..."
by Tobeeto dudy flappucine March 24, 2017
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