A Main Hoe is the main girl you would do something for. It can be caring about her and knowing she's got your back too or sticking up for her when something bad happens.
You're there for your main hoe until the end.
Bob: "Hey Jim, who is your main hoe?"
Jim: "Lola is my main hoe. I'd do anything for that girl."
Mainhoes- main hoes are your ride or die if somebody get buck on one of them you all buck back if somebody try to jump y'all you all better beat there ass down!!! Because y'all are the main hoes and if you fuck with the main hoes you get the MAIN HOES!!!! Straight Facts!!!
Friend #1 y'all know I love y'all oso much and y'all are my best friends
Friend #2 yessss that's why we are the main hoes
Friend #3 yess and whoever try to fuck with us imma burn there house down
Friend #4 ayeee main hoes Gang Gang
Friend #5 Gang Gang Main Hoes
a slang term for posting or engaging with sexual posts on your main social media account, rather than a secondary one that you’d usually use for that purpose. the phrased spawned on tumblr, after ted cruz liked a vore fetish drawing on his main, verified account.
“real men don’t wait until 4am to get horny on main”