A Main Hoe is the main girl you would do something for. It can be caring about her and knowing she's got your back too or sticking up for her when something bad happens.
You're there for your main hoe until the end.
Bob: "Hey Jim, who is your main hoe?"
Jim: "Lola is my main hoe. I'd do anything for that girl."
by Mario&Luigi March 10, 2014
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A mans primary woman. This is the girl he is willing to actually stand up for and is different from his bitchalong.
If anyone tries to put any moves on my main hoe then it's ownage time.
by ownagetime March 19, 2008
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Mainhoes- main hoes are your ride or die if somebody get buck on one of them you all buck back if somebody try to jump y'all you all better beat there ass down!!! Because y'all are the main hoes and if you fuck with the main hoes you get the MAIN HOES!!!! Straight Facts!!!
Friend #1 y'all know I love y'all oso much and y'all are my best friends

Friend #2 yessss that's why we are the main hoes

Friend #3 yess and whoever try to fuck with us imma burn there house down

Friend #4 ayeee main hoes Gang Gang
Friend #5 Gang Gang Main Hoes
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Erin Holman is my main hoe not pedro would never cheat on and also puts spray tan on ya that makes it look like your severely sun burnt
by legeet dude 4 life March 30, 2018
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