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1.
An uncool person who acts annoying, weird, or childish. They also seem to lose a lot in life.

plural form - loserpantses.
He didn't even return my call - what a loserpants!
by SarahOfKrypton July 15, 2006
 
2.
An uncool person who is a freak, socially inept, awkward, nerdy, and generally a loser, even if he thinks otherwise
Peter usually just sits there awkwardly; he's such a loserpants!
by ssshhhh March 19, 2008