The ability to handle large inhalations of cannabis smoke without coughing. Also applies to other drugs that are commonly smoked, though cannabis in particular can be pretty harsh for inexperienced smokers.
Noob smoker: How the hell can you take such huge hits, Barry?

Barry: I been smoking cigs and weed for so long, the smoke just doesn't bother me anymore. It's like I have leather lungs, you know?
by Grey Matter June 19, 2011
Get the leather lungs mug.