A word-mix of "ker-plop", "fuck-up", and "fumble", meaning:
1) A huge
mistake or
poor decision made by a
dumbass.
2) A person guilty of such dumbassery that the word is applied directly to him/her.
1) *Our
dumbass president makes another
stupid decision* "Well, that was a kerfuckle of a move."
2) *Dumbassery is commited* "Dude, you are such a
king-sized kerfuckle."