A word-mix of "ker-plop", "fuck-up", and "fumble", meaning:
1) A huge mistake or poor decision made by a dumbass.
2) A person guilty of such dumbassery that the word is applied directly to him/her.
1) *Our dumbass president makes another stupid decision* "Well, that was a kerfuckle of a move."
2) *Dumbassery is commited* "Dude, you are such a king-sized kerfuckle."
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