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Used when describing an extremely sexually attractive woman.
Often accompanied by the "hit-it" hand signal.

Also has many derivitives or shortened versions used to express more than just a hot lookin' fanny. Such as: Pow, Powzer, Powpowpow, ect.
"I saw your sister yesterday, KA-FUCKING-POWZER!!!" :fist fist fist:
Ka-Pow by Yellowbeard R!!!! October 24, 2004

sarcastic KA-POW 

an acknowledgment of any good use of sarcasm in a nearby conversation
Jimmy: "Hey, what did the advertisement on the window pane of the liquor pane say?"
Fred: "What?"
Jimmy: "We De-Liver"
Fred: "Wow, that's the funniest joke I've heard in ages."
Ollie: "Sarcastic KA-POW!!!"
sarcastic KA-POW by Forty Two March 10, 2008
(pronounced ka-PAY-yow)lifes cheat code. When used as a battle cry, the next action you take automaticaly succeeds. OR
A loud noise
KAPOW!!!!!!!!!!!(throws a rock and blows up building)
kapow by Spaz De Kat January 9, 2009
Pronounced KA-PAAA-EEWWW!

A cry out of awesomeness, satisfaction or accomplishment.

Can also nonchalantly pronounced, slightly wearily.
Toby: "Look at this sandwich baby, kapow!"

"I just tied my shoelaces, kapow!"

"Amsterdam is just kapow!"

Looking in the mirror. "Kapow!"
Kapow by Uforya June 25, 2010
To utterly destroy and or obliterate something
Kazeem kapowed the kitchen, it looked like a bomb crater afterwards.
Kapow by lissamary May 17, 2010

Pussy Kapow! 

The act of punching a vagina on the sweetspot so that it catches the hole to make a realistic batman noise
Things got a bit boring in the bedroom. Rodney had spilled his daily quota, but Kelly was lying spread-eagled with anticipation of an exciting climax, then it struck that she needed a Pussy Kapow!
Pussy Kapow! by Rydo February 23, 2009