Onion Irrelevance Event Horizon 

The point at which reality becomes so weird that the comedy website The Onion is no longer funny in comparison.

"Did you see that political ad? It's WAY past The Onion Irrelevance Event Horizon."

Onion Irrelevance Event Horizon by InThane May 11, 2010

Dis-irrelevance 

1. to have refuted the claim that a specific thing is irrelevant in a case or situation.

based on the word "relevant" meaning to be on topic, the main word here is irrelevant (relevant's antonym), "dis" would mean to refute (or to remove from) when added to a word (refuting is the goal when using this word).

The relevance of the the prosecutor's comment was objected by the defendant, then their claim was refuted by the prosecutor's evidence, in the presents of their dis-irrelevance they stayed there tongue in somber silence.

Dis-irrelevance by masterpackman December 6, 2011

Milkey's law of irrelevance 

By the time you finish typing a long comment in a chatroom, the subject has changed.

Bob1: my dog is so cool! (John3 is typing) Anne2: Really, what breed is it? Bob1:Jack Russel. Anne2: my aunt has a parrot. Bob1: parrots are so funny. Anne2: Yeah, totally. John3: Cool! I have a dog too! Bob1: Huh? John3: Milkey's law of irrelevance at work. :(.

Milkey's law of irrelevance by J1354 June 19, 2009

Pi Irreverence

When both mathophiles and mathophobes unashamedly or liberally poke fun at mathematics’s most famous or notorious constant π, by cracking jokes and puns, composing haikus and limericks, posing silly and serious pi-related quickies and trickies, and creating pi NFTs.

No mathematical constant other than pi has been under so much public scrutiny: pi irreverence has not only permeated popular culture, but is also potentially linked to extraterrestrial life in other planets or galaxies.

Pi Irreverence by Fasters June 6, 2023

IrrelevanceSyndrome

The syndrome an individual suffers from when they become incoherntly irrelevant.

Person: "Look at Annie, she's a Zendaya stan and watches romcoms! An early sign of IrrelevanceSyndrome!"

IrrelevanceSyndrome by Bttlckr April 23, 2022