Someone or somthing that is annoying you at the time.
"she's a stupid bitch"
"yeah, what a guf"
by Meg October 30, 2004
Top Definition
Gross Upper Fup, the next step beyond the first roll of fat above the female genitalia.
Her fup will become a guf, if she does not regulate her eating and get some exercise.
by JWJ August 29, 2006
A good, uncomplicated fuck.
Ughh, what a day. I really need a GUF, right now.
by Daezed June 19, 2014
GUF - Giant Ugly Face
Wow George, I never realized your girlfriend had such a GUF.
by drshogie January 18, 2011

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