Simply means get out of my business.

More expanded it could be used in a situation involving particularly disgusting woman, man, dog etc.

or if the girl has herpatitis

Overall... the phrase is there use it whenever the opportunity presents itself. this includes (but is not limited too):
Example 1:
Joe: Your a total waist of air
You: Get off my dick

Example 2:
Otherguy22: ur a n00b lrn2ply
You: Get of my dick

Example 3:
Roommate: Your stuff is on my side
You: Get off my dick

or other random outbursts
by gridirondb8t April 23, 2007
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Phrase used to silence faggols when trying to belittle you in front of your friends or bitches.
Faggol: Hey Matt. Hey Amanda. Matt, you're back in town? Did you fail out of school again?

Matt: Get off my dick, you molten cumfart
by pompilot July 22, 2009
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When your God-like aura is so fucking good that people literally WILL NOT leave you the fuck alone.

They crave your attention so badly it is as if they are quite practically salivating at the lips to suck you off. In other words, they be on yo dick.

... but you are not in the mood for a good dick sucking and just want to be left alone...

"GET OFF MY DICK"
Shit homie, my girl won't leave me the F alone dawg... she just won't get off my dick.
by Big Dog #2 March 25, 2022
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Meaning dont kiss up to me . Can also be said like get off is dick
Meek: Oh my gosh homie your album views is so sick like it's secretly my life
Drake: Get off my Dick my n***a
by Seven.klza December 24, 2017
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