2) When something happens that causes you to give up.
I was talking to this girl and I found out she has a boyfriend. It's game over.
Other side effects may include headaches, hunger and thirst, prolonged procrastination, impudence, and poor management for the remainder (if it exists) of one's time.
Woah, did nick just boot-n-rally? i thought it was game over! add another tick to the boot-n-rally tally.